by Angela Guess A new press release reports, ?SAP SE today unveiled a new way for customers to simplify and speed the use of cloud-based people and organizational data across their businesses with the SAP® SuccessFactors® People Central Hub solution. The need for people and organizational data across the enterprise is vital, but integrating this [?]
HR analytics aren't mainstream yet, but they're gaining traction because human capital management is a competitive issue. From recruiting to employee performance and overall HR operations, analytics will have an increasing impact on companies and individuals.
Click to learn more about author Daisy Ridley. Technology is transforming the jobs that we do today. The way the organizations create jobs is increasing the speed and transparency but all of that is creating a lot of data. We are talking about Big Data here. Data and analytics is going to become one of the [?]
by Angela Guess According to a new press release, ?Helping today?s HR organizations transform their data to meet business needs and navigate cloud adoption of key HR systems while maintaining data quality, BackOffice Associates, a worldwide leader in information governance and data stewardship, today unveiled the Human Capital Management (HCM) edition of its dspCloud SaaS [?]
The evolving technology of Predictive Analytics is opening new possibilities for predicting future events by studying past performance. Now that Big Data enables Data Scientists to review massive amounts of data, users can hope that the degree of accuracy in future predictions will only rise.
The specific order of DNA's purines and pyrimidines encodes proteins, but chemically modified bases are important in regulating gene expression. In mammals, most cytosines are methylated when present in the CpG dinucleotide; however, stretches of mammalian DNA containing a high frequency of the CG sequence, termed CpG islands (CGIs), are typically unmethylated. The mechanism by which methylation of CGIs is blocked is unclear. Takahashi et al. interrupted CpG-rich sequences by targeted insertion of CpG-free DNA into CGIs in human pluripotent stem cells, which induced stable, heritable methylation. Some disorders result from improper methylation; this work provides an epigenome-editing tool to develop model systems for understanding CGI methylation in development and disease. It may also enable therapeutic strategies to correct aberrant imprinting diseases.
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The repair of DNA double-strand breaks (DSBs) is mediated via two major pathways, nonhomologous end joining (NHEJ) and homologous recombination (HR) repair. DSB repair is vital for cell survival, genome stability, and tumor suppression. In contrast to NHEJ, HR relies on extensive homology and templated DNA synthesis to restore the sequence surrounding the break site. We report a new role for the multifunctional protein CCCTC-binding factor (CTCF) in facilitating HR-mediated DSB repair. CTCF is recruited to DSB through its zinc finger domain independently of poly(ADP-ribose) polymers, known as PARylation, catalyzed by poly(ADP-ribose) polymerase 1 (PARP-1). CTCF ensures proper DSB repair kinetics in response to ?-irradiation, and the loss of CTCF compromises HR-mediated repair. Consistent with its role in HR, loss of CTCF results in hypersensitivity to DNA damage, inducing agents and inhibitors of PARP. Mechanistically, CTCF acts downstream of BRCA1 in the HR pathway and associates with BRCA2 in a PARylation-dependent manner, enhancing BRCA2 recruitment to DSB. In contrast, CTCF does not influence the recruitment of the NHEJ protein 53BP1 or LIGIV to DSB. Together, our findings establish for the first time that CTCF is an important regulator of the HR pathway.
HR professionals are widely recognized for hiring new talent, minimizing churn, and playing a tremendous role in keeping employees happy and the business running smoothly. But, behind the scenes, the job entails endless HR reporting and compliance requirements. And because most organizations remain dependent on a variety of disparate systems, complex spreadsheets, labor-intensive manual processes and inconsistent data to fulfill these tasks, even the most common reporting or compliance project can quickly become a major headache.
I am well acquainted with tissue culture as a laboratory technique. It was an integral part of my research throughout my doctoral training and during my early years in the pharmaceutical industry. But it wasn't until later in my career that I was introduced to an entirely new form of tissue culture
by Angela Guess A recent press release out of IBM reports, ?Cognitive technology has far reaching implications in Human Resources ? from hiring through onboarding to HR operations, employee engagement and performance. According to an IBM report, HR executives are already recognizing the impact of cognitive and there are several key areas where cognitive capabilities ?
In contrast to conventional multipixel cameras, single-pixel cameras capture images using a single detector that measures the correlations between the scene and a set of patterns. However, these systems typically exhibit low frame rates, because to fully sample a scene in this way requires at least the same number of correlation measurements as the number of pixels in the reconstructed image. To mitigate this, a range of compressive sensing techniques have been developed which use a priori knowledge to reconstruct images from an undersampled measurement set. Here, we take a different approach and adopt a strategy inspired by the foveated vision found in the animal kingdom?a framework that exploits the spatiotemporal redundancy of many dynamic scenes. In our system, a high-resolution foveal region tracks motion within the scene, yet unlike a simple zoom, every frame delivers new spatial information from across the entire field of view. This strategy rapidly records the detail of quickly changing features in the scene while simultaneously accumulating detail of more slowly evolving regions over several consecutive frames. This architecture provides video streams in which both the resolution and exposure time spatially vary and adapt dynamically in response to the evolution of the scene. The degree of local frame rate enhancement is scene-dependent, but here, we demonstrate a factor of 4, thereby helping to mitigate one of the main drawbacks of single-pixel imaging techniques. The methods described here complement existing compressive sensing approaches and may be applied to enhance computational imagers that rely on sequential correlation measurements.
Rapid progress in two-dimensional (2D) crystalline materials has recently enabled a range of device possibilities. These possibilities may be further expanded through the development of advanced 2D glass materials. Zachariasen carbon monolayer, a novel amorphous 2D carbon allotrope, was successfully synthesized on germanium surface. The one-atom-thick continuous amorphous layer, in which the in-plane carbon network was fully sp 2-hybridized, was achieved at high temperatures (>900°C) and a controlled growth rate. We verified that the charge carriers within the Zachariasen carbon monolayer are strongly localized to display Anderson insulating behavior and a large negative magnetoresistance. This new 2D glass also exhibited a unique ability as an atom-thick interface layer, allowing the deposition of an atomically flat dielectric film. It can be adopted in conventional semiconductor and display processing or used in the fabrication of flexible devices consisting of thin inorganic layers.
Dr. Thomas C. Redman, the Data Doc and President of Data Quality Solutions, has written another book that tackles the same issue his firm regularly deals with: Data Quality. Joining his previous works, which include Data Driven: Profiting from Your Most Important Business Asset and Data Quality: The Field Guide, is Getting in Front on Data. This time around, though, Dr. Redman is talking more about the people and the roles they should play in achieving Data Quality rather than providing a step-by-step how-to guide to the topic.