Recently, I visited a few conferences and I noticed a somewhat hidden theme. While a lot of attention was being paid to moving to a (hybrid) cloud-based architecture and what you need for that (such as cloud management platforms), a few presentations showed an interesting overall development that everybody acknowledges but that does not get a lot of close attention: the enormous growth of the amount of digital data stored in the world.
Data is clearly not what it used to be! Organizations of all types are finding new uses for data as part of their digital transformations. Examples abound in every industry, from jet engines to grocery stores, for data becoming key to competitive advantage. I call this new data because it is very different from the financial and ERP data that we are most familiar with. That old data was mostly transactional, and privately captured from internal sources, which drove the client/server revolution.
Telepresence has become a very intelligent business strategy, especially for companies that are spread across multiple sites or for those that have clients in many locations that they need to deal with on a fairly regular basis. Using what is in essence a fairly simple robot, anyone can transport himself to another location, move around through offices and interact face to face with people they might not otherwise ever meet. Granted they?re going to look something like large iPads held up by a couple metal rods riding on top of self-propelled vacuum cleaners, but the experience is still surprisingly effective.
In real estate, there?s a mantra that most agents use of ?location, location, location,? meaning houses that may be equal in many ways will cost more the closer you get to something of value. For example, the San Jose Mercury News recently published a story about a house in Sunnyvale, California, that sold for $782,000 over asking price. Why such a ridiculous amount? Because it?s near Apple?s new campus ? location matters.
Whether your concerns are privacy, security, competitive advantage, intellectual property or risk avoidance, your enterprise needs to be sharing?literally?as little data as possible with employees, contractors and third parties. As obvious as that statement is, it?s stunning how much data is unnecessarily shared with cloud providers and others.
In the late 1990s and early 2000s when it became too difficult for large companies to manage their own WAN footprints, they adopted managed multiprotocol label switching (MPLS) services. These offered a simple connection at every location and offloaded the complexities of building large-scale routed networks from enterprises to the service provider.
Damage done by a 2005 earthquake in Balakot, Pakistan
PHOTO: AGENCJA FOTOGRAFICZNA CARO/ALAMY STOCK PHOTO
Foreshocks are small earthquakes that precede much larger and more damaging earthquakes. The role that these small quakes play in nucleating the mainshock is
Poaching of endangered species is contributing to the loss of biodiversity around the world. In an Essay, Lindenmayer and Scheele argue that publication of location data for endangered or newly discovered species can increase the threats from poaching and can accelerate habitat
This week?s articles identify a repulsive guidance system that controls the recruitment of T cells to germinal centers; a mechanism for controlling the transfer of nutrients from the placenta to early mouse embryos; and the subcellular location of calcium dynamics in astrocytes.
The response of materials to external conditions depends on small-scale features such as defects and grain boundaries. Yau et al. heated gold thin films and used coherent x-ray diffractive imaging to track how these microstructures developed during grain growth (see the Perspective by Suter). The technique allowed nondestructive visualization of the features in three dimensions. The method should help link external stimuli to material response through changes in microstructure, thereby allowing development of novel materials through microstructural engineering.
Science , this issue p. ; see also p. 
Human adenoviruses (HAdVs) cause acute respiratory, ocular, and gastroenteric diseases and are also frequently used as gene and vaccine delivery vectors. Unlike the archetype human adenovirus C5 (HAdV-C5), human adenovirus D26 (HAdV-D26) belongs to species-D HAdVs, which target different cellular receptors, and is differentially recognized by immune surveillance mechanisms. HAdV-D26 is being championed as a lower seroprevalent vaccine and oncolytic vector in preclinical and human clinical studies. To understand the molecular basis for their distinct biological properties and independently validate the structures of minor proteins, we determined the first structure of species-D HAdV at 3.7 Ĺ resolution by cryo-electron microscopy. All the hexon hypervariable regions (HVRs), including HVR1, have been identified and exhibit a distinct organization compared to those of HAdV-C5. Despite the differences in the arrangement of helices in the coiled-coil structures, protein IX molecules form a continuous hexagonal network on the capsid exterior. In addition to the structurally conserved region (3 to 300) of IIIa, we identified an extra helical domain comprising residues 314 to 390 that further stabilizes the vertex region. Multiple (two to three) copies of the cleaved amino-terminal fragment of protein VI (pVIn) are observed in each hexon cavity, suggesting that there could be ?480 copies of VI present in HAdV-D26. In addition, a localized asymmetric reconstruction of the vertex region provides new details of the three-pronged ?claw hold? of the trimeric fiber and its interactions with the penton base. These observations resolve the previous conflicting assignments of the minor proteins and suggest the likely conservation of their organization across different HAdVs.
by Angela Guess A recent press release reports, ?Actility, the industry leader in Low Power Wide Area Networks (LPWAN), today announces the availability of a comprehensive geolocation and tracking solution platform offering breakthrough network-based location capability enabled by LoRaWAN network gateways and infrastructure. The ThingPark Location Service will be available to all IoT solution providers ?
The trifurcation area of the San Jacinto fault zone has produced more than 10% of all earthquakes in southern California since 2000, including the June 2016 M w (moment magnitude) 5.2 Borrego Springs earthquake. In this area, the fault splits into three subparallel strands and is associated with broad V P / V S anomalies. We synthesize spatiotemporal properties of historical background seismicity and aftershocks of the June 2016 event. A template matching technique is used to detect and locate more than 23,000 aftershocks, which illuminate highly complex active fault structures in conjunction with a high-resolution regional catalog. The hypocenters form dipping seismicity lineations both along strike and nearly orthogonal to the main fault, and are composed of interlaced strike-slip and normal faults. The primary faults change dip with depth and become listric by transitioning to a dip of ~70° near a depth of 10 km. The M w 5.2 Borrego Springs earthquake and past events with M > 4.0 occurred on the main faults, whereas most of the low-magnitude events are located in a damage zone (several kilometers wide) at seismogenic depths. The lack of significant low-magnitude seismicity on the main fault traces suggests that they do not creep. The very high rate of aftershocks likely reflects the large geometrical fault complexity and perhaps a relatively high stress due to a significant length of time elapsed since the last major event. The results provide important insights into the physics of faulting near the brittle-ductile transition.